Contribution to new book: Pathobiology of Cancer Regimen-Related Toxicities

Chapter Abstract: “The efficacy of chemotherapy depends on several different patient ­factors, including age, gender, ethnicity, and genetics. A patient’s genetic composition strongly influences how chemotherapeutic agents are absorbed, distributed, metabolized, and excreted by the body. Consequently, variations in genes that are responsible for these activities play a significant role in determining the prognostic outcome for patients. Studying and identifying these associated genes have been main foci of...