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HSUN-HSIEN CHANG

Hsun-Hsien Chang, PhD, MBA

Instructor of Pediatrics and Medicine, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School

Research Scientist, Informatics Program, Childrens’ Hospital Boston

Phone: (617) 919-2183
Email: hsun-hsien.chang@childrens.harvard.edu
News

2012.03.20   Dr. Chang was honored a CHAVI Young Investigator Award, thanks to designing novel computational algorithms and statistical tools to analyze the genomes of HIV infected subjects and defining novel molecules that contribute to the early control of the virus following infection. more>>

2011.02.01   Dr. Chang was the organizer of Special Session on Informatics for Integrated Genomics, 2011 IEEE EMBS Annual Conferrence. more>>

2010.03.12   Dr. Chang received a best paper award in 2010 AMIA Summit on Translational Bioinformatics.

2009.06.01   Dr. Chang was honored a featured reviewer of Computing Reviews. more>>

2009.03.17   Dr. Chang received a best paper award in 2009 AMIA Summit on Translational Bioinformatics.more>>
Profile

[complete CV]

2002-2007   PhD in Computer Engineering, Carnegie Mellon University, Pittsburgh, PA.

1998-2000   MBA, National Chengchi University, Taipei, Taiwan.

1994-1998   BS in Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan.

My Erdos number is 5.
Projects

DynTransNet: Inferring Nonstationary Transciptional Networks from Longitudinal Gene Expression

TNC: Transciptional Network Classifiers

TNC for Lung Cancer: Discrimination between Lung Adenocarcinoma and Squamous Cell Carcinoma

Transcriptional Network for HIV: Transcriptional Network Modulating HIV Viral Load

QIP: Quantum Information Processing
Teaching
Predictive Medicine (MIT / HST ), Harvard/MIT HST.
Selected publications
Books:

  1. Hsun-Hsien Chang, Early Detection of Cardiac Rejection: An MRI Based Approach, VDM Verlag, Saarbucken, Germany, 2009

Chapters in Books:

  1. Hsun-Hsien Chang and Jose M. F. Moura, “Biomedical signal processing” in:Biomedical Engineering and Design Handbook, Myer Kutz (ed.), McGraw Hill, June 2009
  2. Hsun-Hsien Chang, et al. “The network strategy of Disk Inc.” in: Cases in Strategic Management 2001, Dah-Hsian Seetoo (ed.), Bestwise Publishers, Taipei, Taiwan, Chapter 6, pp. 131-150; 2000 (ISBN 957-729-162-7)

Journal Articles:

  1. Hsun-Hsien Chang, Kelly A. Soderberg, Jason A. Skinner, Jacques Banchereau, Damien Chaussabe, Barton F. Haynes, Marco F. Ramoni, and Norman L. Letvin “Transcriptional network predicts viral set point during acute HIV-1 infection,” Journal of American Medical Informatics Association, vol. ?, no. ?, 2012, pp.
  2. Michael J. McGeachie, Ann C. Wu, Hsun-Hsien Chang, Scott T. Weiss, and Kelan G. Tantisira, “ Predicting inhaled corticosteroid response in asthma with two associated SNPs,” The Pharmacogenomics Journal, vol. ?, no. ?, 2012, pp. ?
  3. Hsun-Hsien Chang and Marco F. Ramoni, “ Inferring nonstationary gene networks from longitudinal gene expression microarrays,” Journal of Signal Processing Systems, vol. 65, no. 2, November 2011, pp. 261-273
  4. Hsun-Hsien Chang, Jonathan M. Dreyfuss, and Marco F. Ramoni, “ A transcriptional network signature characterizes lung cancer subtypes,”Cancer, vol. 117, no. 2, January 2011, pp. 353-360 [supplementary website]
  5. Hsun-Hsien Chang, Michael McGeachie, Gil Alterovitz, and Marco F. Ramoni, “Mapping transcription mechanisms from multimodal genomic data,” BMC Bioinformatics, vol. 11, no. S9, October 2010, p S1
  6. Hsun-Hsien Chang and Marco F. Ramoni, “Transcriptional network classifiers,” BMC Bioinformatics, vol. 10, no. S9, September 2009, p S1 [supplementary website]
  7. Hsun-Hsien Chang, Jose M. F. Moura, Yijen L. Wu, and Chien Ho, “Automatic detection of regional heart rejection in USPIO-enhanced MRI,” IEEE Transactions on Medical Imaging, vol. 27, no. 8, August 2008, pp 1095-1106
  8. Hsun-Hsien Chang, “Variational approach to cardiac motion estimation for small animals in tagged magnetic resonance imaging,” Lecture Notes in Computer Science, vol. 4319, December 2006, pp 363-372

International Conference Papers:

  1. Hsun-Hsien Chang and Michael McGeachie, “Phenotype prediction by integrative network analysis of SNP and gene expression microarrays,” Proc. 33rd International Conference of IEEE Engineering in Medicine and Biology Society (EMBC ’11), Boston, MA, August 30-September 3, 2011, pp. 6849-6852 [Invited paper for special session in Bioinformatics for Integrated Genomics,Talk Powerpoint]
  2. Hsun-Hsien Chang, Jonathan J. Smith, and Marco Ramoni, “Inferring nonstationary gene networks from temporal gene expression data,” Proc. IEEE Workshop on Signal Processing Systems 2010 (IEEE SiPS ’10), San Francisco, CA, October 6-9, 2010, pp. 223-228 [Invited paper for special session in Bio-medical Signal Processing Systems,Talk Powerpoint]
  3. Jonathan J. Smith, Hsun-Hsien Chang, and Marco F. Ramoni, “Identifying differentially expressed genes in time series microarrays,” Proc. 24th New England Statistics Symposium, Cambridge, MA, April 16-17, 2010, pp. 38 [Talk Powerpoint]
  4. Hsun-Hsien Chang, Michael McGeachie, and Marco Ramoni, “Mapping transcription mechanisms from multimodal genomic data,” Proc. AMIA Summit on Translational Bioinformatics 2010 (AMIA-STB ’10), San Francisco, CA, March 10-12, 2010, pp. ?? [Talk Powerpoint]
  5. Hsun-Hsien Chang and Marco F. Ramoni, “Robust cross-race gene expression analysis,” Proc. IEEE International Conference Acoustics, Speech, and Signal Processing 2009 (ICASSP ’09), Taipei, Taiwan, April 19-24, 2009, pp. 505-508
  6. Hsun-Hsien Chang and Marco F. Ramoni, “Transcriptional diagnosis by Bayesian networks,” Proc. AMIA Summit on Translational Bioinformatics 2009 (AMIA-STB ’09), San Francisco, CA, March 15-17, 2009, pp. 20-24 [Talk Powerpoint]
  7. Hsun-Hsien Chang and Jose M. F. Moura, “Classification regularized by Cheeger constant,” Proc. IEEE International Conference on Image Processing 2007 (ICIP ’07), San Antonia, TX, September 16-19, 2007, pp. II209-II212
  8. Hsun-Hsien Chang, Jose M. F. Moura, Yijen L. Wu, and Chien Ho, “Diffusion map approach to classifying early stage cardiac dysfunction,” Proc. Workshop on Statistical Signal Processing (SSP ’07), Madison, WI, August 26-29, 2007, pp. 615-619
  9. Hsun-Hsien Chang, Jose M. F. Moura, Yijen L. Wu, and Chien Ho, “Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging,” Proc. 28th International Conference of IEEE Engineering in Medicine and Biology Society (EMBC ’06), New York City, NY, August 30-September 3, 2006, pp. 942-945 [Talk Powerpoint]
  10. Hsun-Hsien Chang, Jose M. F. Moura, Yijen L. Wu, and Chien Ho, “A mutual information approach to automatic detection of heart rejection in MRI,” Proc. 14th Annual Meeting of International Society of Magnetic Resonance in Medicine (ISMRM ’06), Seattle, WA, May 6-12, 2006, p. 1199
  11. Hsun-Hsien Chang, Jose M. F. Moura, Yijen L. Wu, and Chien Ho, “Early detection of rejection in cardiac MRI: A spectral graph approach,” Proc. IEEE International Symposium on Biomedical Imaging 2006 (ISBI ’06), Arlington, VA, April 6-9, 2006, pp. 113-116
  12. Hsun-Hsien Chang, Jose M. F. Moura, Yijen L. Wu, and Chien Ho, “3-D dense cardiac strain reconstruction from tagged MR data set,” Proc. 13th Annual Meeting of International Society of Magnetic Resonance in Medicine (ISMRM ’05), Miami, FL, May 7-13, 2005, p. 2792
  13. Yijen L. Wu, Kazuya Sato, Hsun-Hsien Chang, T. Kevin Hitchens, Jose M. F. Moura, and Chien Ho, “The acute cardiac allograft rejection is heterogeneous and can be non-invasively monitored in vivo with MRI by the twopronged methods,”Proc. 8th Annual Scientific Sessions of Society for Cardiovascular Magnetic Resonance (SCMR ’05), San Francisco, CA, January 21-23, 2005
  14. Yijen L. Wu, Kazuya Sato, Ying Sun, Hsun-Hsien Chang, T. Kevin Hitchens, Jose M. F. Moura, and Chien Ho, “Non-invasive early detection of acute cardiac allograft rejection by MRI in rodent model,” Proc. 12th Annual Meeting of International Society of Magnetic Resonance in Medicine (ISMRM ’04), Kyoto, Japan, May 15-21, 2004
  15. Yijen L. Wu, Kazuya Sato, Ying Sun, Hsun-Hsien Chang, John Williams, T. Kevin Hitchens, Jose M. F. Moura, and Chien Ho, “The two-pronged approach for non-invasive early detection of acute cardiac allograft rejection by MRI in a rodent transplantation model,” Proc. 12th Annual Meeting of International Society of Magnetic Resonance in Medicine (ISMRM ’04), Kyoto, Japan, May 15-21, 2004
  16. Hsun-Hsien Chang, Jose M. F. Moura, Yijen L. Wu, Kazuya Sato, and Chien Ho, “Reconstruction of 3D dense cardiac motion from tagged MR sequences,” Proc. IEEE International Symposium on Biomedical Imaging 2004 (ISBI ’04), Arlington, VA, April 15-18, 2004, pp. 880-883 [Talk Powerpoint]

Technical Reports:

  1. Hsun-Hsien Chang, “An introduction to error-correcting codes: From classical to quantum,” Quantum Theory Group, Carnegie Mellon University, 2005 (arXiv: quant-ph/0602157)
  2. Hsun-Hsien Chang, “Implementation of a blind equalizer with TMS320C30,” National Science Council Report, June 1998 (NSC 87-2815-C-007-017-E)